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X-WR-CALNAME:Centre for HIV Strategic Information
X-ORIGINAL-URL:https://www.hivevaluation.org
X-WR-CALDESC:Events for Centre for HIV Strategic Information
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DTSTART:20200101T000000
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DTSTART;TZID=UTC:20200708T000000
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DTSTAMP:20260514T090314
CREATED:20200711T122136Z
LAST-MODIFIED:20200723T125214Z
UID:772-1594166400-1594166400@www.hivevaluation.org
SUMMARY:23. HIV Drug Resistance Prevention and Assessment
DESCRIPTION:  \n\nBackground\nSince its introduction\, antiretroviral (ARV) drug therapy has dramatically reduced morbidity and mortality associated with HIV infection. The use of combination drug therapies can significantly improve HIV patients’ chances for long-term survival. Unfortunately\, the effectiveness of ARV therapy can be markedly reduced by the emergence of drug resistance. Successful treatment of HIV requires a detailed knowledge of the various mechanisms by which resistance can arise as well as an understanding of strategies for overcoming resistance once it occurs.The aim of this course is to increase understanding of the determinants of HIV drug resistance (HIVDR) and the identification of ways to minimize its spread. HIV drug resistance surveillance is a critical adjunct to all country-level ARV programmes\, as it helps detect the circulation of resistance strains in the early stages of the implementation of the ARV programmes and to prevent transmission of HIVDR. \n \n  \n  \n \nLearning objectives\n \n \nThe key objective of the course is to introduce participants to principles and components of national HIV resistance prevetion and assessment. The course addresses HIV drug resistance early warning indicators (EWI) at ART sites\, EWI data collection tools\, EWI analysis and reporting; Issues in the development of drug resistance during treatment; Resistance testing and interpretation; web-based and freeware tools. Participants will learn how to select representative sentinel sites for monitoring of HIVDR and how to develop protocols for HIVDR surveys which includes development of a budget and timeline. \n \n  \n \nKey topics\n \n \n\nIntroduction to the development of antiretroviral drug resistant strains of HIV during ART\, transmission of drug resistant strains of HIV and the effect of drug resistance on treatment outcomes\nMutations associated with HIV drug resistance (HIVDR)\nTesting for HIVDR in the laboratory\, with a focus on genotyping \nMonitoring ART clinic operations to minimize HIV drug resistance (“HIV drug resistance Early Warning Indicator”)\nEpidemiologic and statistical considerations in setting up\,implementing\, and analyzing results from a survey or research study\nSurveillance of pre-treatment HIV DR in individuals initiating ART\nSurveillance of acquired HIV DR  \nInformation technology tools and applications for HIV drug resistance surveys\nWHO recommendations for development of a national HIVDR prevention and assessment strategy\nOrganization of a national HIVDR working group; developing a national plan\n\n \n  \n  \n \nTeaching Methods\n \n \nLectures\, hands-on workshops\, discussions \n \n  \n \nTarget Audience\n \n \nFocal persons in national AIDS programmes who are responsible for HIV drug resistance prevention and assessment\, epidemiologists\, public health professionals\, virologists. \n \n  \n \nDuration\n \n \nThe course takes place in five days. \n \n  \n \nPartners\n \n \n\nWorld Health Organization\, HQ\nUniversity College London\nUniversity Hospital for Infectious Disease „Dr. Fran Mihaljević“\n\n \n  \n \n \n 
URL:https://www.hivevaluation.org/training-course/hiv-drug-resistance-prevention-and-assessment/
CATEGORIES:Courses on HIV Programme Implementation and Evaluation
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